IMPACT OF PREGNANCY RELATED HORMONES ON DRUG METABOLIZING ENZYME AND TRANSPORT PROTEIN CONCENTRATIONS IN HUMAN HEPATOCYTES

Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications.Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes.However, the impact of PRHs on hepatic concentrations of non-CYP drug-meta

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The evaluation of the critical wind speed that overturns a vehicle with space-averaged instantaneous wind velocity

Under the existing method based on a detailed equation for evaluating the wind speed that can cause a vehicle to overturn, it is assumed that the crosswind blows the vehicle at the same wind speed uniformly over the entire length of the vehicle body along the track.However, taking into consideration the actual wind state, there is a wind speed dist

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The effects of protective lung ventilation on regional cerebral oxygen saturation in intracranial tumor operation during dura opening: study protocol for a randomized controlled trial

Abstract Objective The objective of this trial is to investigate the effects of protective lung ventilation on regional cerebral oxygen saturation (rSO2) during dura opening, that is from Ta (after dura opening) to Tb (before dura closing), in patients undergoing intracranial tumor surgery.Methods This is a randomized controlled trial which will be

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Weighted Gene Co-Expression Network Analysis Identifies Specific Modules and Hub Genes Related to Hyperlipidemia

Background/Aims: The present study attempted to identify the potential key genes Pedal Bottom Set and pathways of hyperlipidemia, and to investigate the possible mechanisms associated with them.Methods: The array data of GSE3059 were downloaded, including thirteen samples of hyperlipidemia from the Gene Expression Omnibus (GEO) database.The weighte

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