Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes
Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications.Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (CYPs) in human hepatocytes.However, the impact of PRHs on hepatic concentrations of non-CYP drug-meta